Introduction:

Introduction: In esophageal squamous cell carcinoma (ESCC), lymph node (LN) metastasis is associated with poor survival. Emerging evidence has demonstrated elevated CD8+ T-cell levels in metastatic LNs following immunotherapy and increased chemoresistance. Through this case study，see how spatial transcriptome sequencing helps in elucidating the the underlying regulatory mechanisms of CD8+ T cells in chemoresistant/metastatic patients.